![]() This contrasting relationship has been reported in multiple studies, 9–15 as well as the large Prospective Studies Collaboration meta-analysis. 1 For example, in a case-control study nested in a health maintenance organization, Tirschwell et al 8 found that having a TC in the top quintile (mean, 290 mg/dL or 7.5 mmol/L), versus the lowest quintile, was associated with an increased ischemic stroke risk (odds ratio, 1.6 95% CI, 1.3–1.9) and a decreased intracerebral hemorrhage risk (OR, 0.6 95% CI, 0.4–1.0). High levels of total cholesterol (TC) and LDL (low-density lipoprotein) cholesterol (LDL-C) are both associated with an increased risk of ischemic stroke, whereas low levels are associated with an increased risk of intracerebral hemorrhage. ![]() When total stroke is subtyped into ischemic and hemorrhagic stroke, contrasting relationships with serum lipids are found. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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